RESUMEN
Hyperglycemia with or without blood glucose in diabetes range is an emerging finding not uncommonly encountered in patients with COVID-19. This work is to investigate the association between serum alpha-1-antitrypsin, hyperglycemia, and clinical outcomes in COVID-19, and community-acquired pneumonia, gastric cancer and renal cell carcinoma. Alpha-1-antitrypsin levels in serum was determined by the immunoturbidimetric method. We have set the level of alpha-1-antitrypsin in patients with community-acquired pneumonia and COVID-19 with or without hyperglycemia. Levels of alpha-1-antitrypsin in COVID-19 patients with hyperglycemia who survived > those who did not survive. Concentration of alpha-1-antitrypsin levels in COVID-19 men-patients with hyperglycemia who survived was significantly higher than compared with COVID-19 women-patients with hyperglycemia who survived. The obtained data convincingly demonstrate the value of testing the level of alpha-1-antitrypsin in the blood as one of the important indicators of the effectiveness of cancer diagnosis and prognosis.
RESUMEN
Clinical manifestations in the abdominal cavity of a woman in labor, discovered during an urgent cesarean section at 41 weeks of gestation 2 months after an acute form of COVID-19, are described. The materials of medical documentation were analyzed and the features of the course of pregnancy by trimester, urgent cesarean section, postoperative period, laboratory parameters, ultrasound data, cardiotocography, fetal condition at birth and three days later were determined. Presentation of case. 33-year-old pregnant woman (pregnant for the first time) had COVID-19 at 26 weeks of gestation. At a cesarean section for urgent indications at 41 weeks of gestation during the revision of the abdominal cavity was found that the visceral peritoneum of the uterus along the anterior and posterior surfaces, fallopian tubes, wide and round uterus ligaments, ovaries and parietal peritoneum of the pelvis, areas of the serous intestinal layer were with expressive signs of edema covered with vesicular rash, in places in the conglomerate, which were bleeding. There was no abdominal effusion. The child was born with 7–8 points Apgar score and had a negative PCR result for COVID-19. Placenta measuring 25 x 21 x 5.0 x 0.5 cm with multiple petrification, single red heart attacks. The shells are distinctly yellow-gray-green in color. The umbilical cord is 70 cm long and usual color. Amniotic fluid is clear. The early and late postoperative periods and the postpartum period proceeded without complications. At once the disorders in the blood coagulation system, immune system, positive COVID-19 IgG and IgM were identified in mother. Videin, Magniсum-antistress, preparations of acetylsalicylic acid and for the comprehensive support of the physiological state of the intestine were used in the complex treatment of the postpartum period. Conclusion. COVID-19 disease is pathology with many unknowns. Therefore, each clinical observation is important for studying of its course. Post-COVID syndrome and long-COVID syndrome have individual characteristics. Collective experience will contribute to the definition of an algorithm for the therapy of patients and personalized dispensary observation after an acute period.